Depletion in a mixed fuel

Hello everyone,
I want to perform depletion calculations for a mixed fuel. Do I just need to set depletion for UO2 or do I also need to set it for the mixed fuel?

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Additionally, I’ve noticed a significant slowdown in calculations when I layer the fuel pin. This seems abnormal. Could it be a performance issue due to repetitive surfaces? As far as I know, TRIPOLI has similar issues, but I’m not sure if OpenMC has the same problem. Do I need additional settings in this case?
Thanks for your help!